If Cancer Is Anaerobic Why Use Antiangiogenesis

In my efforts to fight my cancer naturally I have run across quite a lot of belief systems that aren’t necessarily based on science. I don’t want to call it quackery because, in my opinion, quackery is dismissive and insulting to those people who have passed on links and articles in an effort to help. Finally, I am taking B17 which has often been called quackery and, in my opinion, unjustly. In my travels on the web I have constantly heard a few clichés over and over. Some of them are that I should toke up (smoke pot), everyone has cancer, cancer is acidic, I should eat cottage cheese and more. One of these cancer paradigms is that cancer is anaerobic (does not like oxygen). Now, I know that some of these ideas have merit but I have a question about the last. Why? Because, top cancer specialists are using something called Antiangiogenesis to fight cancer. So, if cancer is anaerobic why use antiangiogenesis to fight cancer?

What Is Antiangiogenesis?

Most of our cells make tiny little capillaries designed to feed themselves. This process is called angiogenesis. Now, if the process is going normally then you will see normal cell growth. When it goes wrong then cell growth is abnormal and disease can result. If too many of these capillaries are made then the cell is basically being overfed and, often, you will see runaway cell growth. If it is too slow and not enough capillaries are made then, often, the cell will die or, again disease will manifest.

It seems that some cancers have a unique quality that makes them vulnerable to certain forms of treatment. Most cancers seem to overproduce these capillaries and, if you can switch off these triggers that cause these capillaries to form, then the cells die. The good news is that a number of these drugs have been created and, in some cases, are very successful. The better news is that there are even some foods that will shut off these triggers. Here’s a TED Talk by a top cancer researcher who is working in this area.

TED Talk

If Cancer Is Anaerobic Why Use Antiangiogenesis

Just search the web for something like “cancer and oxygen” or “cancer is anaerobic” and you will be swamped with articles, videos and discussion groups that all say the same thing. Cancer is anaerobic. If cancer is anaerobic why use antiangiogenesis food and drugs to fight it. My instincts tell me that cancer is NOT anaerobic and so does my common sense. If cancer is anaerobic then it would not die when oxygen rich capillaries are prevented from growing. The cancer would not starve if cancer was anaerobic and you denied it oxygen. It might be the denial of nutrients that causes this “starvation” but here’s a quote from “The Oncologist”.

To grow beyond a diameter of approximately 1 mm, newly developing tumors must form their own vascular network and blood supply, which they accomplish either by incorporating preexisting host vessels or by forming new microvessels through the influence of tumor angiogenesis factors. However, the newly formed vascular network differs greatly from that found in normal tissue, typically displaying a broad range of structural and functional abnormalities, including dilations, incomplete or absent endothelial linings and basement membranes, leakiness, irregular and tortuous architecture, arteriovenous shunts, blind ends, and a lack of contractile wall components and pharmacological/physiological receptors. These abnormalities lead to irregular and sluggish blood flow, thereby diminishing the delivery of O2 (and nutrients) to the tumor cells, with the resultant development of hypoxic or even anoxic areas. The oxygenation status of the tumor can be worsened further by increases in diffusion distances, which occur when the tumor cells spread beyond the distance that allows adequate delivery of O2 by the blood vessels (>70 μm). Additionally, diminished tumor oxygenation and subsequent hypoxia can be induced or exacerbated by a reduced O2 transport capacity of the blood due to the presence of cancer-related or cancer treatment-induced anemia. Read More

 Is Cancer Anaerobic?

So, it seems that there are some contradictions in what is typically said about cancer being anaerobic and what some leading cancer specialists are saying about antiangiogenesis being used to fight cancer. It seems to me that at a bare minimum not all cancers are anaerobic and maybe none are. It seems that the idea of starving cancer is a new and effective way to kill some cancers. I think it cannot hurt to start eating some of the foods recommended to fight cancer.

The Warburg Effect

There are some additional ideas that may also play into the “starving cancer” idea. It is called the Warburg Effect. In 1931 Oto Warburg was given the Nobel Prize in Physiology or Medicine. His work included an investigation of the metabolism of cancer cells.

Otto Warburg observed that cancer cells’ metabolism is different than the one of normal adult cells. Normal adult cells use a small energy plant located inside them to produce most of their energy needs from oxygen, this is an aerobic process. In contrast, cancer cells rely mainly on the first part of the energy production process dependant on glucose (sugar), this is an anaerobic process. The anaerobic process is called glycolysis. Read More

So, Antiangiogenesis Treatments seem to have merit and, in my opinion, it doesn’t matter if we are starving the cancer of oxygen or glucose or both. It seems to me that both oxygen and glucose are needed by the cancer cell. Antiangiogenesis seems promising to me.

What Foods Have Antiangiogenic Properties?

Green Tea, Red Grapes, Strawberries, Red Wine, Blackberries, Bok Choy, Raspberries, Kale, Blueberries, Soy Beans, Oranges, Ginseng, Grapefruit, Maitake Mushrooms, Lemons, Licorice, Apples, Tumeric, Pineapple, Nutmeg, Cherries, Artichokes, Lavender,  Pumpkin, Sea Cucumber, Tuna, Parsley, Garlic, Tomato, Olive Oil, Grape Seed Oil, Dark Chocolate

Well, after reading these food items I know what I’ll be eating…..DARK CHOCOLATE! 🙂  It seems that a number of these foods have antiangiogenic properties BUT I don’t know exactly which is most potent. So, my strategy is going to be to focus on foods that I am already using to fight cancer like garlic. You can see a list of foods that I’m using to fight cancer here.

Also, if you watch the video, you will notice that he talks about using extracts from strawberries and other foods. So, that means he is probably doing most of these experiments IN VITRO. In vitro means “in the glass”. In other words, test tubes or something outside the body. In Vivo means inside a living thing which is totally different considering the digestion process. If you would like to read more about this then you can read this post where I review the whole process. I think it’s worth a look.  🙂  Well…..I will be adding these food items to my list of cancer fighting foods under a special section for antiangiogenic foods.

Will this work on my carcinoid tumors? Who knows but hey it’s only food. In the interim I will be researching this more. If you have anything to add please feel free. 🙂

Keep Figting,

Ed – To find out how to use my images on your blog for free – Click Here



    • Yeah, it was pretty interesting BUT notice he said things like “strawberry extracts” and similar statements. All of that testing seems to be done “in vitro” (test tubes etc) not “in vivo” (in a living thing). So…..who knows how much you have to eat….or if it really works when you digest the food etc. Still, I will be looking to incorporate SOME of these foods into my diet….especially the ones that overlap with my “anticancer food list”.

  1. If Cancer Is Anaerobic Why Use Antiangiogenesis?

    In general it probably can’t hurt as long as it’s just food rather than meds. Fasting is also said to starve tumors yet detox normal cells. But, of course, if your already underweight, which we often are, that’s not a plan. And the implication here is that these capillaries are not much up to the task of delivering oxygen anyway.

    There’s a theory that one of the triggers that causes cell to wack out on us like this is that they are not getting enough oxygen to generate energy and so revert to a more primative form of energy production requiring fermentation, in place of burning oxygen, hence the excessive insulin receptors and the need for sugar to survive, and also why they seem to lose their normal communication connection with the rest of the body.

    I find this perspective worth my consideration, even if it supports the idea that cancer cells are anaerobic. I downloaded and printed the following document and eventually out of curiosity read the whole thing for other perspectives. Haven’t bought their products but am now taking CoQ10 (Ubiquinol) on top of a lot of other supplements. http://www.cancerfightingstrategies.com/oxygen-and-cancer.html#sthash.YzNiOp6t.dpbs

    Thank you for doing this blog, Ed. I hope you are feeling well now and even more so each day!

  2. Hi Ed,

    So glad to hear that you’re feeling well and really do appreciate your sharing the PRRT adventure. There’s a lot happening in this arena and first-hand experience is invaluable, so thanks so much for taking the time and effort to share this with us.

    And, it is, isn’t it, an adventure dealing with NETs, even sometimes a cliff hanger or roller coaster ride! But the way I look at is that, “hey, I’m here to tell the story!” Mine started with a dx in 2010 and a flare up last July. The same as you, having NETs, makes me want to help others along the way.

    My mind is a sponge now for data about how tumors behave, or should I say misbehave! And I think in Technicolor rather than black and white, which means rather than good or bad, right or wrong – it’s more like going up in an airplane and looking for the big picture or using a microscope to examine the minutiae in order to identify openings to healthy work arounds.

    So, yes, I think we need fruit and whole grains in our diet and yes, artificial processed sugar serves us in no way. An important take away here, though, is that tumors have 16 insulin receptors for every 1 found on a normal cell. What does that mean? It’s to our advantage to reign in sugar, and that means all sugar plus starch that easily forms sugar, that is as much as reasonably possible within a balanced diet.

    I don’t know about you, but for me Sandostatin LAR causes drug-induced diabetes, which so far has stayed borderline. Consequently I strictly avoid processed sugar, alcohol, and caffeine; I test for glucose each morning and take herbs to help balance this. But then each morning, I also split a smoothy shake with my husband, which gives each of us 1 pint containing several things with natural sugar such as milk, a banana, frozen blueberries plus other nutrient-dense foods like protein powder, seeds, nuts and garden fresh Kale.

    The very best wishes to you for healthy Holidays! — Carol

    • Sorry it took so long for me to reply to you but I didn’t get a notification that you had commented. I don’t know why. I’m glad you got something from my PRRT posts. You’re right, we need to share with others. You know, I keep reading contradicting articles about the sugar but I know one thing….eating healthy cannot hurt and eating “cancer fighters” absolutely cannot hurt. So, that is what I do. I have never really been on Sandostatin. I received 2 shots and my “doctor” (notice the quotes) took me off of it. I was about to lose them anyway. They didn’t know anything about Net/Carcinoid cancer AND they worked at Sloan. 🙁 Well, onward and upward, right. 🙂

  3. Pingback: Pasta with Butternut Sauce Is A Cancer Fighting Recipe - Carcinoid-Cancer.com

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