Pass It On: Links About Cancer 11/01/2015

This post is part of a section on my blog called “Pass It On”. It’s a collection of links that I am passing on to you for your reference. I’ll post into this section about once a month. If you find something interesting then…pass it on!

Natural Ways to Fight Cancer

The glyphosate-based herbicide Roundup is an endocrine (hormone) disruptor in adult male rats, a new study shows. The lowest dose tested of 10 mg/kg bw/d (bodyweight per day) was found to reduce levels of corticosterone, a steroid hormone produced in the adrenal glands. No other toxic effects were seen at that dose, so if endocrine disruption were not being specifically looked for, there would be no other signs that the dose was toxic. Read More

The statement, released today by the Endocrine Society, also adds support to the somewhat controversial idea that even minute doses of these chemicals can interfere with the activity of natural hormones, which play a major role in regulating physiology and behavior. Read More

Nineteen EU member states have requested opt-outs for all or part of their territory from cultivation of a Monsanto genetically-modified crop, which is authorized to be grown in the European Union, the European Commission said on Sunday. Read More

The drop in soda consumption represents the single largest change in the American diet in the last decade and is responsible for a substantial reduction in the number of daily calories consumed by the average American child. Read More

Medical Information

Good news from Vienna, ECC 2015, the European Cancer Congress,
announced by Philippe Ruszniewski, MD, head of gastroenterology and pancreatology at Beaujon Hospital, in Clichy, France. “Treatment with the novel peptide receptor radionuclide therapy (PRRT) Lutathera significantly increased progression-free survival (PFS) over octreotide LAR (Sandostatin) in patients with advanced midgut neuroendocrine tumors (NETs), according to findings from the phase III NETTER-1 trial presented at the 2015 European Cancer Congress.” Read More

In conclusion, we have developed Hu5F9-G4, a humanized blocking anti-CD47 antibody that exerts anti-leukemic effects both in vitro and in vivo leading to the eradication of AML in xenotransplant mouse models and a major survival benefit. Significantly, toxicokinetic studies of Hu5F9-G4 in non-human primates showed that Hu5F9-G4 could be safely administered intravenously at doses able to achieve potentially therapeutic serum levels, using a priming-maintenance dosing strategy. These studies provide the pre-clinical rationale for the development of Hu5F9-G4 as a therapeutic either as a single agent or in combination with other cancer-targeting antibodies. Read More

Phase I trial with a dose-escalation stage that will enroll patients with relapsed or refractory lymphoma who are transfusion independent with relatively normal baseline blood counts, thus better enabling characterization of potential changes in hematologic parameters that could occur upon CD47 blockade. Once the optimal dose and schedule of TTI-621 administration have been established, the Company expects to study safety and anti-tumor activity in a variety of expansion cohorts of patients. These will include patients with acute myeloid leukemia, myelodysplastic syndrome, as well as several other advanced hematologic malignancies. Read More

Stanford researchers previously found that all kinds of cancer protect themselves from programmed cell removal by displaying a “don’t-eat-me” signal called CD47 to counteract the “eat-me” signal presented by CRT on cancer cells. Clinical researchers in the Stanford Cancer Institute are now conducting a clinical trial of a therapy to see if blocking cancer’s CD47 “don’t-eat-me” signal will allow macrophages to engulf and destroy cancer cells displaying the CRT “eat-me” signal. Read More

Berg, a private company that uses artificial intelligence to discover new drugs and diagnostics, will help England’s national genomics project mine DNA and health data from thousands of British citizens for potential drug targets. Read More

Stanford investigators have discovered if that they block the CD47 “don’t-eat-me” signal through the use of anti-CD47 antibodies, macrophages will consume and destroy cancer cells. Deadly human cancers have been diminished or eliminated in animal models through the use of anti-CD47 antibody. Read More

researchers dream of the day they can force tumor cells to morph back to the normal cells they once were. Now, researchers on Mayo Clinic’s Florida campus have discovered a way to potentially reprogram cancer cells back to normalcy. Read More

In a one-two punch, a familiar diabetes drug reduced tumors faster and prolonged remission in mice longer than chemotherapy alone, apparently by targeting cancer stem cells, report Harvard Medical School researchers in the Sept. 14 advance online Cancer Research. Read More

A somatic mutation in the ATRX gene has recently been shown as a potential molecular marker for aggressive brain tumors, such as gliomas, neuroblastomas and pancreatic neuroendocrine tumors.  Read More

General Information

I want you to know that my vision and goal in Denver is to build a “home” for you, where neuroendocrine is known and understood by all.  I’ve spent the last 6 months working hard with the Healing NET Foundation so we can advocate and educate.  But, I have also been looking around the country for just the right place to work.  I completely understand your frustrations.  Many in the healthcare field are not familiar with the word neuroendocrine.  Or, they just pegged me as a surgeon and wanted me to do that all day. Read More

The U.S. Secret Service ordered hundreds of parents and their cancer-stricken children out of Lafayette Square on Saturday night, barricading the park for at least two hours and disrupting the group’s plans for a candlelight vigil to raise awareness and research funding for childhood cancer, participants said. Read More

London-based tech startup Figshare has a pretty incredible mandate – use technology to completely overhaul how academic research is available. In turn, it hopes this will better society by speeding up scientific, economic, and sociological discovery. Read More

And The Final Jeapordy Question is…”What Is Propaganda?”  – Monsanto enlisted Condé Nast publications, and appealed to non-governmental organizations (NGOs) in need of donations, to help produce a celebrity-driven video series in support of genetically modified organisms (GMOs). While we all like to believe that our scientific/rational brains see through the transparent marketing, public relations rhetoric exists because it greatly sedates critical thought. Read More

When you take a moment to reflect on the history of product development at Monsanto, what do you find? Here are twelve products that Monsanto has brought to market. See if you can spot the pattern. Read More

If you are an American, there is a 1 in 3 chance that you will get cancer during your lifetime. If you are a man, the odds are closer to 1 in 2. And almost everyone in America either knows someone who currently has cancer or who has already died from cancer. But it wasn’t always this way. Back in the 1940s, only one out of every sixteen Americans would develop cancer. Something has happened that has caused the cancer rate in this nation to absolutely explode, and it is being projected that cancer will soon surpass heart disease and become the leading cause of death in the United States Read More

If you find this useful then pass it on,
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